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The Role of Tocilizumab in Inflammatory Diseases and Its Monitoring through Arterial Blood Gas (ABG) Analysis
Tocilizumab works by binding to the IL-6 receptor, preventing IL-6 from interacting with its receptor on the surface of cells. This leads to a reduction in inflammation and a decrease in the production of pro-inflammatory cytokines.
- BE helps to assess the severity of metabolic acidosis or alkalosis.
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- Day 1 post-dose: ABG shows pH 7.41, PaCO₂ 38, PaO₂ 68, PaO₂/FiO₂ = 113.
- Day 2 post-dose: FiO₂ reduced to 40%; ABG: pH 7.39, PaCO₂ 40, PaO₂ 82, PaO₂/FiO₂ = 205.
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