Yes, but with a caveat. Topaz Video AI is excellent for increasing resolution, but it struggles when combined with Twixtor. The AI adds "hallucinated" detail that Twixtor misreads as motion. Run Topaz AI before Twixtor, or find native BDRip upscales. Currently, native 4K releases of High School DxD are limited, so AI-upscaled 4K from a master 1080p source is your best bet.
When applying the effect in After Effects or Premiere Pro, ensure your "Input Frame Rate" matches your footage (usually 23.976). Use "Motion Weighted" blending for the smoothest results without warping. rias gremory twixtor clips for editing 4k