Even if you have DirectX 12, Resident Evil 5 specifically requires legacy files from the DirectX End-User Runtimes .
He yanked the plug. The monitors died. The room plummeted into silence. Download Re5dx9.exe Resident Evil 5
If you are trying to launch on a modern PC and hitting a wall, you likely encountered an error regarding the re5dx9.exe file. This executable is the DirectX 9 version of the game launcher, which many players still use to ensure compatibility with certain mods or older hardware configurations. What is re5dx9.exe? Post: How to Safely Get the d3dx9_42