To optimize Cities: Skylines for a low-end PC, you must prioritize reducing the load on your CPU and RAM, as these are the primary bottlenecks for the game's simulation and asset management.
Build "rural" towns. Use the 81 Tiles mod, but only build on 2 tiles. Spread out your buildings to reduce traffic congestion (traffic AI is heavy on CPU). Avoid huge industrial complexes. cities skylines settings for low end pc better
This mod changes how the UI and certain game elements are rendered, often providing a 5-15 FPS increase instantly. Essential Graphics Settings To optimize Cities: Skylines for